What is the role of radiotherapy in the treatment of glioblastoma multiforme (GBM)?

Updated: Jul 01, 2019
  • Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, FAANS  more...
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Answer

Key points regarding radiotherapy for GBM include the following: [7, 8]

  • The addition of radiotherapy to surgery increases survival. [9, 10]

  • The responsiveness of GBM to radiotherapy varies.

  • Interstitial brachytherapy is of limited use and is rarely used.

  • Radiosensitizers, such as newer chemotherapeutic agents, [11] targeted molecular agents, [12, 13] and antiangiogenic agents [13] may increase the therapeutic effect of radiotherapy. [14]

  • Radiotherapy and/or radiosurgery for recurrent GBM is controversial.


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