What is the prognosis of insulinoma?

Updated: May 31, 2020
  • Author: Zonera Ashraf Ali, MBBS; Chief Editor: Neetu Radhakrishnan, MD  more...
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Approximately 90-95% of insulinomas are benign. Long-term cure with complete resolution of preoperative symptoms is expected after complete resection.

Recurrence of benign insulinomas was observed in 5.4% of patients in a series of 120 patients over a period of 4-17 years. The same diagnostic and therapeutic approach was recommended, including surgical exploration and tumor resection.

Patients may develop nonfunctioning metastatic disease to the liver up to 14 years after insulinoma resection. [64] Note that some insulinomas are indolent (depending on the tumor biology), resulting in prolonged survival.

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