Which medications are used in the treatment of insulinoma?

Updated: May 31, 2020
  • Author: Zonera Ashraf Ali, MBBS; Chief Editor: Neetu Radhakrishnan, MD  more...
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Answer

Pharmacologic treatment is designed to prevent hypoglycemia and, in patients with malignant tumors, to reduce the tumor burden. Agents used in this therapy include the following:

  • Diazoxide: Reduces insulin secretion

  • Hydrochlorothiazide: Counteracts edema and hyperkalemia secondary to diazoxide and potentiates its hyperglycemic effect

  • Somatostatin analogs (octreotide, lanreotide): Prevent hypoglycemia

  • Everolimus: For patients with metastatic insulinoma and refractory hypoglycemia


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