What are primitive polypoid granular cell tumors (GCTs)?

Updated: Dec 29, 2018
  • Author: Vladimir O Osipov, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

The primitive polypoid granular cell tumor is another rare subset, which manifests as exophytic polypoid skin lesions at any site or in a person of any age. The lesions are characterized by nuclear pleomorphism, frequent mitoses, and poor immunohistochemical reactions. They are not aggressive tumors. Most likely, they represent a nonimmunoreactive phenotype of granular cell tumor. [21] In 2005, Lazar and Fletcher published a series of similar cases. Only one of 13 cases gave rise to a local lymph node metastasis. In this case, the patient had no recurrence and is currently disease-free 70 months after lymphadenectomy. [22]


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