Which immunohistochemical findings are characteristic of granular cell tumors (GCTs)?

Updated: Nov 12, 2020
  • Author: Vladimir O Osipov, MD; Chief Editor: E Jason Abel, MD  more...
  • Print

Granular cell tumors have an uncertain histogenesis. Many immunohistochemical and ultrastructural studies suggest a Schwann cell origin. [17]

The tumor cells stain positively for S-100 protein, neuron-specific enolase, and NK1-C3 in almost all cases. Positivity with stains for myelin-associated P0 and P2 proteins, myelin basic protein, and Leu-7 is less consistent. [18]

The tumor cells are nonimmunoreactive for epithelial, muscle, endothelial, and glial cell markers. This is useful for differentiating a granular cell tumor from other diagnostic possibilities.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!