Which physical findings are characteristic of granular cell tumors (GCTs)?

Updated: Dec 29, 2018
  • Author: Vladimir O Osipov, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

Nodules are usually solitary but may be multiple in up to 10% of cases (patients with 26 and 52 tumors are on record). Multiple granular cell tumors have been reported in patients with LEOPARD (lentigenes, electrocardiographic conduction anomalies, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth, deafness) syndrome (Noonan syndrome), a rare autosomal dominant, disorder caused by a mutation in the protein tyrosine phosphatase, nonreceptor type 11 gene (PTPN11). [2, 10]

An association between multiple cutaneous granular cell tumors and neurofibromatosis has been suggested, but remains unproven. [11]


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