Which medications in the drug class Antineoplastic agents are used in the treatment of Papillary Thyroid Carcinoma?

Updated: Jun 18, 2020
  • Author: Ponnandai S Somasundar, MD, MPH, FACS; Chief Editor: Neetu Radhakrishnan, MD  more...
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Answer

Antineoplastic agents

These medications inhibit cell growth and proliferation and may be helpful in palliating symptoms in metastatic disease.

Cisplatin (Platinol)

Inhibits DNA synthesis and, thus, cell proliferation by causing DNA crosslinks and denaturation of double helix. Dose is related to body surface area.

Doxorubicin (Adriamycin)

Inhibits topoisomerase II and produces free radicals, which may cause destruction of DNA. Combination of these 2 events, in turn, can inhibit growth of neoplastic cells.


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