When is thyroid hormone replacement therapy indicated in papillary thyroid carcinoma (PTC)?

Updated: Jun 18, 2020
  • Author: Ponnandai S Somasundar, MD, MPH, FACS; Chief Editor: Neetu Radhakrishnan, MD  more...
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Subclinical hypothyroidism may also occur. However, the clinical significance of subclinical hypothyroidism, and the benefits of treating it, remain uncertain. [63, 64]

Guidelines from the American Association of Clinical Endocrinologists (AACE) and the American Association of Endocrine Surgeons include recommendations for follow-up in patients with thyroid carcinoma. [7]

Patients require lifelong thyroid hormone replacement therapy, especially after total thyroidectomy. Treatment consists of levothyroxine in a dosage of 2.5-3.5 mcg/kg/d. A patient who has had a thyroidectomy without parathyroid preservation requires vitamin D and calcium supplementation for life.

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