What is included in long-term monitoring of papillary thyroid carcinoma (PTC) following radioactive iodine ablation and a negative thyroid ultrasound?

Updated: Jun 18, 2020
  • Author: Ponnandai S Somasundar, MD, MPH, FACS; Chief Editor: Neetu Radhakrishnan, MD  more...
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Answer

In pattients who were treated with radioactive iodine ablation and who have a negative thyroid ultrasound, a stimulated thyroglobulin level 8</ref>

A meta-analysis demonstrated that an undetectable serum thyroglobulin finding during thyroid hormone suppression of TSH is often misleading. Patients with endogenous subclinical hyperthyroidism have an increased risk of cardiovascular disease and dysrhythmia. [62] Accordingly, the authors propose a new surveillance guideline for patients who have undergone total or near-total thyroidectomy and radioactive iodine ablation and have no clinical evidence of residual tumor with a serum thyroglobulin level less than 1 mcg/L during thyroid hormone suppression of TSH.


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