What is the role of Hashimoto’s thyroiditis in the etiology of papillary thyroid carcinoma (PTC)?

Updated: Jun 18, 2020
  • Author: Ponnandai S Somasundar, MD, MPH, FACS; Chief Editor: Neetu Radhakrishnan, MD  more...
  • Print

Patients with a history of Hashimoto thyroiditis are at increased risk for papillary thyroid cancer. In a study by Bradly et al, the overall incidence of incidental papillary carcinoma (IPC) in benign operatively resected thyroid disease was 12%, with Hashimoto thyroiditis being associated with the highest rate of IPC. [37] According to this study and others, the association of IPCs with Hashimoto thyroiditis may indicate a link to thyroid cancer. [38]

A study by Spencer concluded that in patients with Hashimoto thyroiditis, thyroglobulin autoantibody trends may be used as a surrogate differentiated thyroid carcinoma tumor marker and are superior to thyroglobulin immunometric assay findings, provided that the same method is used. [39] Because of the increased risk of PTC, total thyroidectomy may be considered appropriate in patients with Hashimoto thyroiditis and large follicular adenoma requiring operation.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!