What is the role obesity in the etiology of papillary thyroid carcinoma (PTC)?

Updated: Jun 18, 2020
  • Author: Ponnandai S Somasundar, MD, MPH, FACS; Chief Editor: Neetu Radhakrishnan, MD  more...
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One of every six papillary thyroid cancers (PTC) and two thirds of all large PTC tumors in the United States from 1995 to 2015 were attributable to overweight or obesity, according to an analysis of data from three large national US databases. Kitahara et al estimated that total relative risk for PTC was 1.26 for persons who are overweight (body mass index [BMI] 25.0-29.0 kg/m2) and 1.30 for those who are obese (BMI ≥30.0), compared with persons with normal-weight BMI (18.5-24.9). Risk for large (> 4 cm) PTCs was increased nearly 3-fold (hazard ratio [HR] = 2.93, 95% CI 1.25-6.87) with overweight, and was increased more than 5-fold (HR = 5.42, 95% CI 2.24-13.1) with obesity. [20]

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