Which medications in the drug class Antidotes, Other are used in the treatment of Tumor Lysis Syndrome?

Updated: Dec 07, 2018
  • Author: Alan K Ikeda, MD; Chief Editor: Wafik S El-Deiry, MD, PhD  more...
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Answer

Antidotes, Other

Sodium polystyrene sulfonate is an exchange resin that can be used to treat mild to moderate hyperkalemia. Each milliequivalent of potassium is exchanged for 1 mEq of sodium. Agents to treat hyperphosphatemia are also used.

Sodium polystyrene sulfonate (Kayexalate, Kalexate, Kionex)

Sodium polystyrene sulfonate is used in the second stage of therapy to reduce total-body potassium. This agent exchanges sodium for potassium and binds it in the gut, primarily in the large intestine. Its onset of action after oral administration is 2-12 hours and is longer when administered rectally.

Aluminum hydroxide (AlternaGEL)

Aluminum hydroxide has been shown to be an effective phosphate binder. Because of their potential for toxicity, however, aluminum salts are not used as first-line therapy.

Sevelamer hydrochloride (Renagel, Renvela)

This is a polymeric phosphate binder for oral administration. It does not contain aluminum; thus, aluminum intoxication is not a concern.


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