What are the NCCN recommendations for management of non-clear cell stage IV renal cell cancer (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

For patients with non–clear cell histology, NCCN recommendations for systemic therapy include the following:

  • Clinical trial (preferred)
  • Sunitinib (preferred)
  • Axitinib
  • Bevacizumab
  • Bevacizumab + erlotinib for selected patients with advanced papillary RCC, including hereditary leiomyomatosis–associated RCC (HLRCC)
  • Bevacizumab + everolimus for selected patients with advanced papillary RCC including HLRCC
  • Cabozantinib
  • Erlotinib
  • Everolimus
  • Lenvatinib + everolimus
  • Nivolumab
  • Pazopanib
  • Sorafenib
  • Temsirolimus (category 1 for poor-prognosis patients;hcategory 2A for other risk groups)

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