What are the ESMO clinical practice guidelines for the diagnosis and staging of renal cell carcinoma (RCC)?

Updated: May 20, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
  • Print

The ESMO 2016 updated clinical practice guidelines included the following recommendations for the diagnosis and staging of RCC [75] :

  • Diagnosis is usually suggested by ultrasound and further investigated by CT scan. Magnetic resonance imaging (MRI) may provide additional information in investigating local advancement and venous involvement by tumour thrombus.

  • Contrast-enhanced chest, abdominal, and pelvic CT is mandatory for staging; In case of an allergy to CT contrast medium,  a high-resolution CT scan of the chest without contrast medium, together with an abdominal MRI may be used.

  • Unless clinically indicated, the use of bone scan or CT (or MRI) of the brain is not recommended for routine clinical practice

  • Positron emission tomography is not a standard investigation in the diagnosis and staging of RCC

  • A diagnostic biopsy is required before treatment with ablative therapies; it is also indicated in patients with metastatic disease before initiating systemic treatment.

  • The final histopathologic diagnosis, classification, grading, and evaluation of prognostic factors should be based on the nephrectomy specimen when available

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!