What are the NCCN recommendations for the workup of renal cell carcinoma (RCC)?

Updated: Feb 19, 2021
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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The NCCN  guidelines for kidney cancer recommend the following as part of the initial workup [19] :

  • History and physical examination
  • Complete blood count, comprehensive metabolic panel, and urinalysis
  • Abdominal/pelvic CT or abdominal MRI, with contrast when clinically indicated
  • Chest x-ray
  • Bone scan, brain MRI, chest CT, if clinically indicated
  • If multiple renal masses, ≤46 years, or family history, consider genetic evaluation

In addition, the NCCN recommends considering needle biopsy of small lesions if clinically indicated. The NCCN also recommends considering urine cytology and ureteroscopy if urothelial carcinoma is suspected (eg, a central mass is present).

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