What is the role of megestrol and antiestrogens in the treatment of renal cell carcinoma (RCC)?

Updated: Feb 19, 2021
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Multiple studies have been conducted using megestrol (Megace) in the treatment of renal cell carcinoma. No benefit has been shown except for appetite stimulation, so megestrol is currently not recommended. Antiestrogens such as tamoxifen (100 mg/m2/d or more) and toremifene (300 mg/d) have also been tried, with a response rate as low as that of most chemotherapeutic agents.  With the availability of targeted therapy that improves survival, the role of hormonal therapy is unclear; in the author's opinion, these agents should not be considered as a part of the routine treatment algorithm.

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