What is the role of cabozantinib (Cabometyx) in the treatment of renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

Cabozantinib (Cabometyx) is a small-molecule tyrosine kinase inhibitor. In April 2016, cabozantinib was approved for advanced RCC in patients who have received prior antiangiogenic therapy. Approval was based on a randomized, open-label study of 658 patients with RCC who had progressed after VEGF receptor–targeted therapy. Treatment with the cabozantinib significantly improved progression-free survival compared with everolimus. Median progression-free survival was 7.4 months with cabozantinib treatment versus 3.8 months with everolimus (P<0.0001). Median overall survival also significantly improved with cabozantinib compared with everolimus (21.4 mo vs 16.5 mo; P=0.0003). However, cabozantinib had significant side effects that necessitated a dose reduction in 60% or more of patients. [52]


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