What is the role of lenvatinib (Lenvima) in the treatment of renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

In May 2016, the FDA approved lenvatinib (Lenvima) in combination with everolimus for advanced RCC following 1 prior antiangiogenic therapy. Approval was based on a randomized, phase II open-label, multicenter trial of 153 patients with advanced clear-cell RCC who had progressed on or within 9 months of stopping vascular endothelial growth factor (VEGF) receptor targeted therapy. Progression-free survival (PFS) was significantly improved with lenvatinib in combination with everolimus compared with everolimus alone (14.5 mo vs 5.5 mo; P=0.0005).  When the 2 monotherapies were analyzed, there was a modest improvement in PFS with lenvatinib 7.4 months (P=0.048). [45]

Lenvatinib is a small molecule tyrosine kinase (TK) inhibitor that inhibits the kinase activities of VEGF receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Also inhibits other TKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular function.


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