What is the role of temsirolimus (Torisel) in the treatment of renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

Temsirolimus (Torisel) inhibits mammalian target of rapamycin (mTOR), which is a serine/threonine kinase important in the regulation of cell growth and division. Genes involved with the response to hypoxia (hypoxia-inducible factor [HIF] pathway) are also upregulated by mTOR and are believed to be central to the pathogenesis of kidney cancers. The FDA has approved temsirolimus for the treatment of advanced renal cell carcinoma at an intravenous (IV) dose of 25 mg weekly until progression.


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