What are the adverse effects of sunitinib in the treatment of renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

Major toxicities (grade II or higher) of sunitinib include fatigue (38%), hypothyroidism (in as many as 30%), diarrhea (24%), nausea (19%), dyspepsia (16%), stomatitis (19%), and decline in cardiac ejection fraction (11%). Dermatitis occurred in 8%, and hypertension occurred in 5% of patients.

Hypertension induced by sunitinib may correlate with a significantly higher probability of response and better disease-free and overall survival. [33] Likewise, onset of hypothyroidism in patients treated with sunitinib may portend better response. [34]


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