What are the histologic characteristics of collecting duct carcinoma in renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

Collecting duct carcinoma is an unusual variant characterized by a very aggressive clinical course. This disease tends to affect younger patients and may present as local or widespread advanced disease. These cells can have three different types of growth patterns: acinar, sarcomatoid, and tubulopapillary. The sarcomatoid variant, which can occur with any histologic cell type, is associated with a significantly poorer prognosis.

The following table provides a brief summary of the 5 histologic subtypes of renal cell carcinoma.

Table. Pathologic Classification of Renal Cell Carcinoma (Open Table in a new window)

Cell Type

Features

Growth Pattern

Cell of Origin

Cytogenetics

Clear cell

Most common

Acinar or sarcomatoid

Proximal tubule

3p-

Chromophilic

Bilateral and multifocal

Papillary or sarcomatoid

Proximal tubule

+7, +17, -Y

Chromophobic

Indolent course

Solid, tubular, or sarcomatoid

Cortical collecting duct

Hypodiploid

Oncocytic

Rarely metastasize

Tumor nests

Cortical collecting duct

Undetermined

Collecting duct

Very aggressive

Papillary or sarcomatoid

Medullary collecting duct

Undetermined

Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics.


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