What are the factors for predicting survival in patients with metastatic renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
  • Print
Answer

Motzer et al identified 5 prognostic factors for predicting survival in patients with metastatic renal cell carcinoma. [14] These factors were used to categorize patients with metastatic renal cell carcinoma into 3 risk groups. Patients in the favorable-risk group (zero risk factors) had a median survival of 20 months, and patients with intermediate risk (1 or 2 risk factors) had a median survival of 10 months, whereas patients in the poor-risk group (3 or more risk factors) had a median survival of only 4 months. The prognostic factors are as follows:

  • Low Karnofsky performance status (< 80%)

  • High serum lactate dehydrogenase (LDH) level (>1.5 times upper limit of normal ULN])

  • Low hemoglobin (below lower limit of normal [LLN])

  • High "corrected" serum calcium (>10 mg/dL)

  • No previous nephrectomy


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!