What are the prognostic criteria used in the Memorial Sloan-Kettering Cancer Center (MSKCC)/Motzer score for metastatic renal cell carcinoma (RCC)?

Updated: Feb 19, 2021
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Two similar prognostic systems are commonly used to calculate risk in patients with metastatic renal cell carcinoma (RCC). The Memorial Sloan-Kettering Cancer Center (MSKCC)/Motzer score includes the following criteria [14] :

  • Time from diagnosis to systemic treatment less than 1 year
  • Hemoglobin concentration below the lower limit of normal (LLN)
  • Serum calcium concentration > 10 mg/dL (2.5 mmol/L)
  • Lactate dehydrogenase (LDH) level more than 1.5 times the upper limit of normal (ULN)
  • Performance status ( Karnofsky) less than 80%

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