What is the prognosis of renal cell carcinoma (RCC)?

Updated: May 20, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

Renal cell carcinoma (RCC) is the tenth leading cause of cancer deaths in males in the United States. In men, deaths from kidney cancer decreased 3.9% between 1990 and 2005; in women, deaths decreased by 7.8% during the same period. Overall, 5-year relative survival increased from 51% to 67% between 1975-1977 and 1996-2004. [1] The 5-year survival rates initially reported by Robson in 1969 were 66% for stage I renal carcinoma, 64% for stage II, 42% for stage III, and only 11% for stage IV. [11, 12] Except for stage I, these survival statistics have remained essentially unchanged for several decades.

A study by Abdollah et al found that the rate of complications, transfusions, and in-hospital mortality was higher in patients treated with cytoreductive nephrectomy than in those who underwent nephrectomy. Risk is further increased in patients who are older, have higher comorbidity, or need secondary surgical procedures. [15]


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