What is the role of smoking in the etiology of renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

A number of environmental and genetic factors have been studied as possible causes for renal cell carcinoma (RCC). Cigarette smoking doubles the risk of renal cell carcinoma and contributes to as many as one third of all cases. The risk appears to increase with the amount of cigarette smoking in a dose-dependent fashion. Smoking has also been associated with advanced disease at presentation.


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