What is the first-line therapy for metastatic renal cell carcinoma (RCC)?

Updated: May 21, 2019
  • Author: Kush Sachdeva, MD; Chief Editor: E Jason Abel, MD  more...
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Answer

In recent years, clinical trials have established targeted therapy as the most common first-line treatment in patients with metastatic disease. Although the optimal treatment strategy continues to evolve, three agents that target angiogenesis (sunitinib, bevacizumab, and pazopanib) and a mammalian target of rapamycin (mTOR)–targeted therapy (temsirolimus) have been approved as front-line agents. High-dose interleukin-2 (IL-2) and axitinib can be used in selected patients.


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