What are the NCCN guidelines on adjuvant therapy for stage II or stage III rectal cancer?

Updated: Apr 06, 2021
  • Author: Burt Cagir, MD, FACS; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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For the majority of patients with stage II or stage III rectal cancer, the NCCN recommends the use of ionizing radiation to the pelvis along with adjuvant chemotherapy. Either of the two following sequences of therapy may be used:

  • Chemoradiation therapy preoperatively and chemotherapy postoperatively
  • Chemotherapy followed by chemoradiation therapy, followed by resection

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