Which physical findings are characteristic of hematologic paraneoplastic syndromes?

Updated: Jan 12, 2021
  • Author: Luigi Santacroce, MD; Chief Editor: Wafik S El-Deiry, MD, PhD  more...
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Answer

Thrombocytosis (>500,000 platelets/dL) can be observed in patients with cancer of the lung, breast, digestive organs, or reproductive organs. This thrombocytosis leads to the following two phenomena:

  • Migrating thrombophlebitis that is resistant to standard anticoagulant therapy and involves the arm veins, the inferior vena cava, and the jugular veins; it usually appears as oval formations along small and medium-size veins, accompanied by cutaneous necrosis.

  • Marantic (nonbacterial) endocarditis characterized by growths developing on the heart valves that may break off and form emboli


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