Which clinical history findings are characteristic of endocrine paraneoplastic syndromes?

Updated: Jan 12, 2021
  • Author: Luigi Santacroce, MD; Chief Editor: Wafik S El-Deiry, MD, PhD  more...
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Endocrine symptoms related to paraneoplastic syndromes usually resemble the more common endocrine disorders. Cushing syndrome, accompanied by hypokalemia, very high plasma ACTH levels, and increased serum and urine cortisol concentrations, is the most common example of an endocrine disorder linked to a malignancy. [24, 25, 5, 26] Many tumors (eg, small cell cancer of the lung) can produce Cushing syndrome via ectopic production of ACTH or ACTH-like molecules.

Syndrome of inappropriate antidiuretic hormone (SIADH) is the most common paraneoplastic endocrine syndrome associated with small cell lung cancer (SCLC). Reports range from 10-45% of patients developing SIADH during their illness. [27]

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