Which clinical history findings are characteristic of hematologic paraneoplastic syndromes?

Updated: Jan 12, 2021
  • Author: Luigi Santacroce, MD; Chief Editor: Wafik S El-Deiry, MD, PhD  more...
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Symptoms related to erythrocytosis or anemia, [19] thrombocytosis, disseminated intravascular coagulation (DIC), and leukemoid reactions may result from many types of cancers.

In some cases, symptoms result from migrating vascular thrombosis (ie, Trousseau syndrome) [20, 21] occurring in at least two sites. Leukemoid reactions, characterized by the presence of immature white blood cells in the bloodstream, are usually accompanied by hypereosinophilia and itching. These reactions are typically observed in patients with lymphomas or cancers of the lung, breast, stomach, or pancreas. Cryoglobulinemia may occur in patients with lung cancer or pleural mesothelioma.

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