Which clinical history findings are characteristic of rheumatologic paraneoplastic syndromes?

Updated: Jan 12, 2021
  • Author: Luigi Santacroce, MD; Chief Editor: Wafik S El-Deiry, MD, PhD  more...
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Answer

Paraneoplastic arthropathies arise as rheumatic polyarthritis or polymyalgia, particularly in patients with myelomas; lymphomas; acute leukemia; malignant histiocytosis; and tumors of the colon, pancreas, prostate, and CNS. [17] Hypertrophic osteoarthropathy may be observed in patients with lung cancers, pleural mesothelioma, or phrenic neurilemmoma.

Scleroderma may precede direct evidence of tumor. The widespread form is typical of malignancies of the breast, uterus, and lung (both alveolar and bronchial forms). The localized form is characteristic of carcinoids and lung tumors (bronchoalveolar forms).

Systemic lupus erythematosus (SLE) may develop in patients with lymphomas or cancers of the lung, breast, or gonads.

Secondary amyloidosis of the connective tissues is a rare presentation in patients with myeloma, renal carcinoma, and lymphomas.


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