What are the ESMO guidelines for the use of pancreaticoduodenectomy (Whipple procedure) for the treatment of pancreatic cancer?

Updated: Mar 07, 2019
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Guidelines on pancreatic cancer from the European Society for Medical Oncology include the following treatment recommendations [63] :

  • Complete surgical resection is the only potentially curative treatment available. However, 5-yr overall survival is only 10-20%; long-term survival in node-positive tumors is rare
  • Optimal symptomatic treatment has a prime role in the management of metastatic disease; these patients may require stenting or bypass surgery for obstructive jaundice or gastric outlet obstruction
  • The role of chemotherapy is limited; gemcitabine has been associated with a small survival benefit compared with bolus 5-fluorouracil

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