What is the role of olaparib in the treatment of pancreatic cancer?

Updated: Jan 10, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

In December 2019, olaparib gained FDA approval for adults with germline BRCA-mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. Clinical trial results showed a statistically significant increase of progression-free survival in these patients compared with placebo (7.4 months vs 3.8 months; P = 0.004). [97]


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