What are ASCO recommendations for second-line therapy of stage IV non–small cell lung cancer (NSCLC) in patients with ROS1 rearrangement?

Updated: Jun 05, 2020
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Answer

For patients with ROS1 rearrangement, recommendations include the following:

  • Single-agent crizotinib, if first-line therapy did not include crizotinib
  • Platinum-based therapy with or without bevacizumab, if first-line therapy included crizotinib

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