What is the role of durvalumab in the treatment of stage III non–small cell lung cancer (NSCLC)?

Updated: Jul 15, 2021
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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In February 2018, the FDA approved durvalumab for unresectable, Stage III NSCLC in patients whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy. Approval was based on a randomized trial of 713 patients whose NSCLC had not progressed after completing chemotherapy and radiation. Median progression-free survival for patients taking durvalumab was 16.8 months compared with 5.6 months for patients receiving a placebo (P < 0.001). The median time to death or distant metastasis was longer with durvalumab than with placebo (23.2 months vs. 14.6 months; P< 0.001). [138]

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