How does the efficacy of alectnib compare to crizotinib for the treatment of non–small cell lung cancer (NSCLC)?

Updated: Jul 15, 2021
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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A separate phase III study, the Japanese phase III J-ALEX trial, also demonstrated the benefit of crizotinib in ALK-positive NSCLC. In J-ALEX, 207 Japanese patients with ALK-positive advanced or recurrent NSCLC who had not been previously treated with an ALK inhibitor were randomized to alectinib 300 mg PO BID or 250 mg of crizotinib 250 mg PO BID. The median PFS was 25.9 months in the alectinib arm versus 10.2 months in the crizotinib arm. Alectinib reduced the risk of progression in the CNS by 81% in patients without brain metastases at baseline, and by 49% in patients with brain metastases at baseline. [187]

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