How common are anaplastic lymphoma kinase (ALK) mutations in non–small cell lung cancer (NSCLC)?

Updated: Jun 05, 2020
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Answer

Chromosomal rearrangement of ALK occurs in about 5% of NSCLC cases. In most of these patients, treatment is initiated with crizotinib. This agent is also indicated for NSCLC with ROS-1 mutations. Second-line agents for ALK-positive NSCLC are brigatinib, ceritinib, and alectinib.


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