What is the role of durvalumab in the treatment of non–small cell lung cancer (NSCLC)?

Updated: Jul 15, 2021
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Answer

More recently, consolidation therapy with the anti-programmed death ligand–1 antibody durvalumab following concomitant chemoradiation has shown significant benefit. In a study in 713 patients with stage III NSCLC who did not have disease progression after two or more cycles of platinum-based chemoradiotherapy, median progression-free survival was 16.8 months with durvalumab versus 5.6 months with placebo, and the 18-month progression-free survival rate was 44.2% versus 27.0%. [138]


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