What are the symptoms of mediastinal non–small cell lung cancer (NSCLC)?

Updated: Jun 05, 2020
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Answer

Mediastinal cancers may produce the following signs and symptoms:

  • Dyspnea
  • Postprandial coughing (esophageal)
  • Wheezing
  • Stridor (upper airway obstruction, 2-18%)
  • Hoarseness (left vocal cord paralysis due to recurrent laryngeal nerve impingement, 2-18%)
  • Chylothorax (thoracic duct)
  • Palpitations (pericardial)
  • Dysphagia (enlargement of the subcarinal lymph nodes can cause dysphagia by compressing the middle third of the esophagus)

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