What is the role of thalidomide in the treatment of Kaposi sarcoma (KS)?

Updated: Apr 11, 2019
  • Author: Jessica Katz, MD, PhD, FACP; Chief Editor: Edwin Choy, MD, PhD  more...
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Answer

Because of its highly vascular nature, Kaposi sarcoma has been thought of as a natural target for angiogenesis inhibition. A phase II study of thalidomide in 20 HIV-infected patients with Kaposi sarcoma resulted in a 40% response rate with median duration of response of 7 months. Most of the patients were on HAART. [31]  SImilarly, a phase I/II trial evaluating the efficacy of pomalidomide in 22 patients, 77% of whom had relapsed disease, found a 60% overall response rate in the HIV-positive group. [92]  Combination chemotherapy with antiangiogenic and cytotoxic agents is being considered. [81]


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