Which medications in the drug class Antiviral agents are used in the treatment of Hairy Leukoplakia?

Updated: Aug 05, 2019
  • Author: James E Cade, DDS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Antiviral agents

Nucleoside analogs initially are phosphorylated by viral thymidine kinase to eventually form a nucleoside triphosphate.

Acyclovir (Zovirax)

Acyclovir has affinity for viral thymidine kinase and, once phosphorylated, causes DNA chain termination when acted on by DNA polymerase. Patients experience less pain and faster resolution of lesions when used within 48 hours from onset of an outbreak. Acyclovir may prevent recurrent outbreaks. Early initiation of therapy is imperative.

Valacyclovir (Valtrex)

Valacyclovir is a prodrug that is rapidly converted to the active drug acyclovir. It is more expensive but has a more convenient dosing regimen than acyclovir.

Famciclovir (Famvir)

Famciclovir is a prodrug that when biotransformed into the active metabolite, penciclovir, may inhibit viral DNA synthesis/replication.

Ganciclovir (Cytovene, Vitrasert)

Ganciclovir is indicated for CMV retinitis and the prevention of CMV infection in individuals who are HIV positive.

Foscarnet (Foscavir)

Foscarnet is indicated only for acyclovir-resistant mucocutaneous herpes simplex virus, which occurs almost exclusively in individuals who are HIV positive.

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