Which medications in the drug class Keratolytic agents are used in the treatment of Hairy Leukoplakia?

Updated: Aug 05, 2019
  • Author: James E Cade, DDS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Keratolytic agents

These agents cause cornified epithelium to swell, soften, macerate, and then desquamate.

Podophyllum resin (Pod-Ben-25, Podofin, Podocon-25)

The major active constituent, podophyllotoxin, is a lipid-soluble compound that easily crosses cell membranes. Podophyllotoxin and its derivatives are potent cytotoxic agents that inhibit cell mitosis and deoxyribonucleic acid (DNA). Cell division is arrested, and other cellular processes are impaired, gradually resulting in the disruption of cells.

Podophyllum resin arrests mitosis in the metaphase; the active agent is podophyllotoxin; the type of podophyllum resin used determines strength. American podophyllum contains one fourth the amount of Indian sources. It is used in symptomatic OHL.

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