How is proliferative verrucous leukoplakia differentiated from hairy leukoplakia?

Updated: Aug 05, 2019
  • Author: James E Cade, DDS; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Answer

Proliferative verrucous leukoplakia can have a papillary and roughened surface, which may simulate the corrugated surface of oral hairy leukoplakia. Proliferative verrucous leukoplakia is known for malignant transformation. The two examples on the tongue and gingiva in the images below showed squamous cell carcinoma with biopsy.

 Proliferative verrucous leukoplakia of the latera Proliferative verrucous leukoplakia of the lateral tongue; biopsy showed squamous cell carcinoma.
Proliferative verrucous leukoplakia of the gingiva Proliferative verrucous leukoplakia of the gingiva; biopsy showed squamous cell carcinoma.

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