Which medications in the drug class Antineoplastics, Topoisomerase Inhibitors are used in the treatment of Gastric Cancer?

Updated: May 21, 2019
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Antineoplastics, Topoisomerase Inhibitors

Topoisomerase inhibitors inhibit cell growth and proliferation.

Irinotecan (Camptosar)

Semisynthetic derivative of camptothecin, an alkaloid extract from the Camptotheca acuminate tree. Inactive in its parent form. Converted by the carboxylesterase enzyme to its active metabolite from, SN-38. SN-38 binds to and stabilizes the topoisomerase I-DNA complex and prevents the relegation of DNA after it has been cleaved by topoisomerase I, inhibiting DNA replication.


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