What are the US Multi-Society Task Force on Colorectal Cancer guidelines for the genetic evaluation and management of Lynch syndrome (hereditary non-polyposis colorectal cancer) with regard to gastric cancer?

Updated: May 21, 2019
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
  • Print
Answer

In 2014, the US Multi-Society Task Force on Colorectal Cancer, which included the American College of Gastroenterology, the American Gastroenterological Association Institute, and the American Society for Gastrointestinal Endoscopy, released consensus guidelines for the genetic evaluation and management of Lynch syndrome. With regard to gastric cancer, the task force recommendations were as follows [69] :

  • Consider screening by esophagogastroduodenoscopy (EGD) with biopsy of the gastric antrum in individuals at risk for or diagnosed with Lynch syndrome at age 30−35 years

  • Treat H pylori infection when found

  • Continue surveillance every 2−3 years, based on individual patient risk factors

  • In view of the relatively low risk of gastric cancer and the lack of established benefit, the 2013 revised guidelines from the Mallorca group for European experts does not recommend surveillance for gastric cancer but does recommend screening individuals with Lynch syndrome for the presence of H pylori infection and subsequent eradication if detected. [72]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!