What are the NCCN guidelines for gastric cancer screening in patients with Lynch syndrome (hereditary non-polyposis colorectal cancer)?

Updated: Feb 24, 2020
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Although the NCCN guidelines note that gastric cancer is the second most common extracolonic cancer (after endometrial cancer) in patients with Lynch syndrome, they do not find clear evidence to support screening for gastric, duodenal or small bowel cancer. In selected individuals or families of Asian descent, esophagogastroduodenoscopy (EGD) with extended duodenoscopy (to distal duodenum or into the jejunum) every 3-5 years beginning at age 30-35 can be considered. [71]

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