Which histologic findings are characteristic of gastric cancer?

Updated: May 21, 2019
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Biopsy of any ulcerated lesion should include at least six specimens taken from around the lesion because of variable malignant transformation. In selected cases, endoscopic ultrasonography may be helpful in assessing depth of penetration of the tumor or involvement of adjacent structures.

Histologically, the frequency of different gastric malignancies is as follows [3] :

  • Adenocarcinoma - 90-95%
  • Lymphomas - 1-5%
  • Gastrointestinal stromal tumors (formerly classified as either leiomyomas or leiomyosarcomas) - 2%
  • Carcinoids - 1%
  • Adenoacanthomas - 1%
  • Squamous cell carcinomas - 1%

See Workup for more detail.


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