What is the global incidence of esophageal cancer?

Updated: Apr 10, 2020
  • Author: Muhammad Masab, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Esophageal cancer is the ninth most common cancer and the sixth most common cause of cancer deaths worldwide. [59] It is endemic in many parts of the world, particularly in the third world countries, where it is the fourth most common cause of cancer deaths. [59] Incidence rates are variable worldwide, with the highest rates found in southern and eastern Africa and eastern Asia and the lowest rates in western and central Africa and Central America in both men amd women. [59]

In some regions, such as areas of northern Iran, some areas of southern Russia, and northern China (sometimes called an "esophageal cancer belt"), the incidence of esophageal carcinoma may be as high as 800 cases per 100,000 population. Major risk factors in these areas are not well known but are probably related to the poor nutritional status, including low intake of fruits and vegetables and drinking very hot beverages. Unlike in the United States, squamous cell carcinoma is responsible for 95% of all esophageal cancers worldwide.

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