Which medications in the drug class Antineoplastics, VEGF Inhibitor are used in the treatment of Colon Cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Antineoplastics, VEGF Inhibitor

Vascular endothelial growth factor (VEGF) receptor antagonists disrupt ligand-induced proliferation and migration of human endothelial cells. Angiogenesis requires the binding of signaling molecules (eg, VEGF) to receptors on the surface of normal endothelial cells. When VEGF and other endothelial growth factors bind to their receptors on endothelial cells, signals within these cells are initiated that promote the growth and survival of new blood vessels. When VEGF is bound, angiogenesis is inhibited.

Ramucirumab (Cyramza)

Ramucirumab specifically binds VEGF receptor 2 and blocks binding of VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D. It is indicated for use in combination with FOLFIRI for the treatment of patients with metastatic colorectal cancer (mCRC) whose disease has progressed on a first-line bevacizumab-, oxaliplatin- and fluoropyrimidine-containing regimen.


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