What are the indications for use of pembrolizumab to treat colon cancer?

Updated: Apr 15, 2020
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Consider pembrolizumab for unresectable or metastatic colon cancer that has tested positive for microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR), and has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. [123] Nivolumab, or nivolumab plus ipilimumab are also indicated for MSI-H or dMMR metastatic colorectal cancer which progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. [171]

See also Colon Cancer Treatment Protocols.


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